Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly.
Authors: Authors: Lin SY, Rai R, Li K, Xu ZX, Elledge SJ.
Proc Natl Acad Sci U S A
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A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells.
Authors: Authors: Stegmeier F, Hu G, Rickles RJ, Hannon GJ, Elledge SJ.
Proc Natl Acad Sci U S A
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umuDC and mucAB operons whose products are required for UV light- and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share homology. 1985.
Authors: Authors: Perry KL, Elledge SJ, Mitchell BB, Marsh L, Walker GC.
DNA Repair (Amst)
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A genetic screen for candidate tumor suppressors identifies REST.
Authors: Authors: Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJ.
Cell
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An open letter to Elias Zerhouni.
Authors: Authors: Altman S, Bassler BL, Beckwith J, Belfort M, Berg HC, Bloom B, Brenchley JE, Campbell A, Collier RJ, Connell N, Cozzarelli NR, Craig NL, Darst S, Ebright RH, Elledge SJ, Falkow S, Galan JE, Gottesman M, Gourse R, Grindley ND, Gross CA, Grossman A, Hochschild A, Howe M, Hurwitz J, Isberg RR, Kaplan S, Kornberg A, Kustu SG, Landick RC, Landy A, Levy SB, Losick R, Long SR, Maloy SR, Mekalanos JJ, Neidhardt FC, Pace NR, Ptashne M, Roberts JW, Roth JR, Rothman-Denes LB, Salyers A, Schaechter M, Shapiro L, Silhavy TJ, Simon MI, Walker G, Yanofsky C, Zinder N.
Science
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MAGIC, an in vivo genetic method for the rapid construction of recombinant DNA molecules.
Authors: Authors: Li MZ, Elledge SJ.
Nat Genet
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Dissecting cancer pathways and vulnerabilities with RNAi.
Authors: Authors: Westbrook TF, Stegmeier F, Elledge SJ.
Cold Spring Harb Symp Quant Biol
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Genetic analysis of the kinetochore DASH complex reveals an antagonistic relationship with the ras/protein kinase A pathway and a novel subunit required for Ask1 association.
Authors: Authors: Li JM, Li Y, Elledge SJ.
Mol Cell Biol
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Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase.
Authors: Authors: Ye X, Nalepa G, Welcker M, Kessler BM, Spooner E, Qin J, Elledge SJ, Clurman BE, Harper JW.
J Biol Chem
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Systematic analysis and nomenclature of mammalian F-box proteins.
Authors: Authors: Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW.
Genes Dev
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