Stephen J. Elledge

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital

Professor of Medicine, Brigham and Women's Hospital

617-525-4510

Elledge Lab Website

Additional Websites
Publications

HHMI Investigator

MAGIC, an in vivo genetic method for the rapid construction of recombinant DNA molecules.

Authors: Authors: Li MZ, Elledge SJ.
Nat Genet 2005-03-01
View full abstract on Pubmed

Dissecting cancer pathways and vulnerabilities with RNAi.

Authors: Authors: Westbrook TF, Stegmeier F, Elledge SJ.
Cold Spring Harb Symp Quant Biol 2005-01-01
View full abstract on Pubmed

Genetic analysis of the kinetochore DASH complex reveals an antagonistic relationship with the ras/protein kinase A pathway and a novel subunit required for Ask1 association.

Authors: Authors: Li JM, Li Y, Elledge SJ.
Mol Cell Biol 2005-01-01
View full abstract on Pubmed

Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase.

Authors: Authors: Ye X, Nalepa G, Welcker M, Kessler BM, Spooner E, Qin J, Elledge SJ, Clurman BE, Harper JW.
J Biol Chem 2004-11-26
View full abstract on Pubmed

Systematic analysis and nomenclature of mammalian F-box proteins.

Authors: Authors: Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW.
Genes Dev 2004-11-01
View full abstract on Pubmed

Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.

Authors: Authors: Cortez D, Glick G, Elledge SJ.
Proc Natl Acad Sci U S A 2004-07-06
View full abstract on Pubmed

Chk1 is haploinsufficient for multiple functions critical to tumor suppression.

Authors: Authors: Lam MH, Liu Q, Elledge SJ, Rosen JM.
Cancer Cell 2004-07-01
View full abstract on Pubmed

Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation.

Authors: Authors: Lin SY, Li K, Stewart GS, Elledge SJ.
Proc Natl Acad Sci U S A 2004-04-27
View full abstract on Pubmed

A resource for large-scale RNA-interference-based screens in mammals.

Authors: Authors: Paddison PJ, Silva JM, Conklin DS, Schlabach M, Li M, Aruleba S, Balija V, O'Shaughnessy A, Gnoj L, Scobie K, Chang K, Westbrook T, Cleary M, Sachidanandam R, McCombie WR, Elledge SJ, Hannon GJ.
Nature 2004-03-25
View full abstract on Pubmed

Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein.

Authors: Authors: Tetzlaff MT, Yu W, Li M, Zhang P, Finegold M, Mahon K, Harper JW, Schwartz RJ, Elledge SJ.
Proc Natl Acad Sci U S A 2004-03-09
View full abstract on Pubmed