Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
Cyclin F disruption compromises placental development and affects normal cell cycle execution.
Authors: Authors: Tetzlaff MT, Bai C, Finegold M, Wilson J, Harper JW, Mahon KA, Elledge SJ.
Mol Cell Biol
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SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.
Authors: Authors: Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, Harper JW.
Genes Dev
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Replication protein A-mediated recruitment and activation of Rad17 complexes.
Authors: Authors: Zou L, Liu D, Elledge SJ.
Proc Natl Acad Sci U S A
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Dicer is essential for mouse development.
Authors: Authors: Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ, Mills AA, Elledge SJ, Anderson KV, Hannon GJ.
Nat Genet
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BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.
Authors: Authors: Xu L, Wei Y, Reboul J, Vaglio P, Shin TH, Vidal M, Elledge SJ, Harper JW.
Nature
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Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.
Authors: Authors: Osborn AJ, Elledge SJ.
Genes Dev
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Multiple tumor suppressor pathways negatively regulate telomerase.
Authors: Authors: Lin SY, Elledge SJ.
Cell
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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.
Authors: Authors: Zou L, Elledge SJ.
Science
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Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability.
Authors: Authors: Morales JC, Xia Z, Lu T, Aldrich MB, Wang B, Rosales C, Kellems RE, Hittelman WN, Elledge SJ, Carpenter PB.
J Biol Chem
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Genomic instability and endoreduplication triggered by RAD17 deletion.
Authors: Authors: Wang X, Zou L, Zheng H, Wei Q, Elledge SJ, Li L.
Genes Dev
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