Stephen J. Elledge

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital

Professor of Medicine, Brigham and Women's Hospital

617-525-4510

Elledge Lab Website

Additional Websites
Publications

HHMI Investigator

Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.

Authors: Authors: Cortez D, Glick G, Elledge SJ.
Proc Natl Acad Sci U S A 2004-07-06
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Chk1 is haploinsufficient for multiple functions critical to tumor suppression.

Authors: Authors: Lam MH, Liu Q, Elledge SJ, Rosen JM.
Cancer Cell 2004-07-01
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Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation.

Authors: Authors: Lin SY, Li K, Stewart GS, Elledge SJ.
Proc Natl Acad Sci U S A 2004-04-27
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A resource for large-scale RNA-interference-based screens in mammals.

Authors: Authors: Paddison PJ, Silva JM, Conklin DS, Schlabach M, Li M, Aruleba S, Balija V, O'Shaughnessy A, Gnoj L, Scobie K, Chang K, Westbrook T, Cleary M, Sachidanandam R, McCombie WR, Elledge SJ, Hannon GJ.
Nature 2004-03-25
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Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein.

Authors: Authors: Tetzlaff MT, Yu W, Li M, Zhang P, Finegold M, Mahon K, Harper JW, Schwartz RJ, Elledge SJ.
Proc Natl Acad Sci U S A 2004-03-09
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Cyclin F disruption compromises placental development and affects normal cell cycle execution.

Authors: Authors: Tetzlaff MT, Bai C, Finegold M, Wilson J, Harper JW, Mahon KA, Elledge SJ.
Mol Cell Biol 2004-03-01
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SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.

Authors: Authors: Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, Harper JW.
Genes Dev 2003-12-15
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Replication protein A-mediated recruitment and activation of Rad17 complexes.

Authors: Authors: Zou L, Liu D, Elledge SJ.
Proc Natl Acad Sci U S A 2003-11-25
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Dicer is essential for mouse development.

Authors: Authors: Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ, Mills AA, Elledge SJ, Anderson KV, Hannon GJ.
Nat Genet 2003-11-01
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BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.

Authors: Authors: Xu L, Wei Y, Reboul J, Vaglio P, Shin TH, Vidal M, Elledge SJ, Harper JW.
Nature 2003-09-18
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