Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling.
Authors: Authors: Wang Y, Shirogane T, Liu D, Harper JW, Elledge SJ.
Cell
View full abstract on Pubmed
MDC1 is a mediator of the mammalian DNA damage checkpoint.
Authors: Authors: Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ.
Nature
View full abstract on Pubmed
The DASH complex component Ask1 is a cell cycle-regulated Cdk substrate in Saccharomyces cerevisiae.
Authors: Authors: Li Y, Elledge SJ.
Cell Cycle
View full abstract on Pubmed
53BP1, a mediator of the DNA damage checkpoint.
Authors: Authors: Wang B, Matsuoka S, Carpenter PB, Elledge SJ.
Science
View full abstract on Pubmed
Checking on the fork: the DNA-replication stress-response pathway.
Authors: Authors: Osborn AJ, Elledge SJ, Zou L.
Trends Cell Biol
View full abstract on Pubmed
Cancer. BRCA2 enters the fray.
Authors: Authors: Wilson JH, Elledge SJ.
Science
View full abstract on Pubmed
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.
Authors: Authors: Hirao A, Cheung A, Duncan G, Girard PM, Elia AJ, Wakeham A, Okada H, Sarkissian T, Wong JA, Sakai T, De Stanchina E, Bristow RG, Suda T, Lowe SW, Jeggo PA, Elledge SJ, Mak TW.
Mol Cell Biol
View full abstract on Pubmed
The two faces of BRCA2, a FANCtastic discovery.
Authors: Authors: Stewart G, Elledge SJ.
Mol Cell
View full abstract on Pubmed
The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II.
Authors: Authors: Bachant J, Alcasabas A, Blat Y, Kleckner N, Elledge SJ.
Mol Cell
View full abstract on Pubmed
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Authors: Authors: Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NP.
Nature
View full abstract on Pubmed