Stephen J. Elledge, Ph.D.
Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.
Multiple tumor suppressor pathways negatively regulate telomerase.
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.
Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability.
Authors: Authors: Morales JC, Xia Z, Lu T, Aldrich MB, Wang B, Rosales C, Kellems RE, Hittelman WN, Elledge SJ, Carpenter PB.
J Biol Chem
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J Biol Chem
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Genomic instability and endoreduplication triggered by RAD17 deletion.
Authors: Authors: Wang X, Zou L, Zheng H, Wei Q, Elledge SJ, Li L.
Genes Dev
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Genes Dev
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Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling.
Authors: Authors: Wang Y, Shirogane T, Liu D, Harper JW, Elledge SJ.
Cell
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Cell
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MDC1 is a mediator of the mammalian DNA damage checkpoint.
Authors: Authors: Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ.
Nature
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Nature
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The DASH complex component Ask1 is a cell cycle-regulated Cdk substrate in Saccharomyces cerevisiae.
53BP1, a mediator of the DNA damage checkpoint.
Authors: Authors: Wang B, Matsuoka S, Carpenter PB, Elledge SJ.
Science
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Science
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Checking on the fork: the DNA-replication stress-response pathway.