Stephen J. Elledge, Ph.D.
Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
Cancer. BRCA2 enters the fray.
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.
Authors: Authors: Hirao A, Cheung A, Duncan G, Girard PM, Elia AJ, Wakeham A, Okada H, Sarkissian T, Wong JA, Sakai T, De Stanchina E, Bristow RG, Suda T, Lowe SW, Jeggo PA, Elledge SJ, Mak TW.
Mol Cell Biol
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Mol Cell Biol
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The two faces of BRCA2, a FANCtastic discovery.
The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II.
Authors: Authors: Bachant J, Alcasabas A, Blat Y, Kleckner N, Elledge SJ.
Mol Cell
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Mol Cell
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Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Authors: Authors: Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NP.
Nature
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Nature
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Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway.
The BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients.
The mitotic spindle is required for loading of the DASH complex onto the kinetochore.
Authors: Authors: Li Y, Bachant J, Alcasabas AA, Wang Y, Qin J, Elledge SJ.
Genes Dev
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Genes Dev
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Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin.
Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway.