Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.
Authors: Authors: Zou L, Elledge SJ.
Science
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Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability.
Authors: Authors: Morales JC, Xia Z, Lu T, Aldrich MB, Wang B, Rosales C, Kellems RE, Hittelman WN, Elledge SJ, Carpenter PB.
J Biol Chem
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Genomic instability and endoreduplication triggered by RAD17 deletion.
Authors: Authors: Wang X, Zou L, Zheng H, Wei Q, Elledge SJ, Li L.
Genes Dev
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Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling.
Authors: Authors: Wang Y, Shirogane T, Liu D, Harper JW, Elledge SJ.
Cell
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MDC1 is a mediator of the mammalian DNA damage checkpoint.
Authors: Authors: Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ.
Nature
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The DASH complex component Ask1 is a cell cycle-regulated Cdk substrate in Saccharomyces cerevisiae.
Authors: Authors: Li Y, Elledge SJ.
Cell Cycle
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53BP1, a mediator of the DNA damage checkpoint.
Authors: Authors: Wang B, Matsuoka S, Carpenter PB, Elledge SJ.
Science
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Checking on the fork: the DNA-replication stress-response pathway.
Authors: Authors: Osborn AJ, Elledge SJ, Zou L.
Trends Cell Biol
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Cancer. BRCA2 enters the fray.
Authors: Authors: Wilson JH, Elledge SJ.
Science
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Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.
Authors: Authors: Hirao A, Cheung A, Duncan G, Girard PM, Elia AJ, Wakeham A, Okada H, Sarkissian T, Wong JA, Sakai T, De Stanchina E, Bristow RG, Suda T, Lowe SW, Jeggo PA, Elledge SJ, Mak TW.
Mol Cell Biol
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