Stephen J. Elledge, Ph.D.
Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
Towards genetic genome projects: genomic library screening and gene-targeting vector construction in a single step.
Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints.
Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints.
ATR and ATRIP: partners in checkpoint signaling.
Mrc1 transduces signals of DNA replication stress to activate Rad53.
Authors: Authors: Alcasabas AA, Osborn AJ, Bachant J, Hu F, Werler PJ, Bousset K, Furuya K, Diffley JF, Carr AM, Elledge SJ.
Nat Cell Biol
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Nat Cell Biol
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Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.
Authors: Authors: Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, Elledge SJ.
Science
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Science
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Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p.
Authors: Authors: Gasch AP, Huang M, Metzner S, Botstein D, Elledge SJ, Brown PO.
Mol Biol Cell
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Mol Biol Cell
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Reduced expression and impaired kinase activity of a Chk2 mutant identified in human lung cancer.
Authors: Authors: Matsuoka S, Nakagawa T, Masuda A, Haruki N, Elledge SJ, Takahashi T.
Cancer Res
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Cancer Res
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Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function.
Direct DNA binding by Brca1.
Authors: Authors: Paull TT, Cortez D, Bowers B, Elledge SJ, Gellert M.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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