Stephen J. Elledge, Ph.D.
Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.
Authors: Authors: Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, Elledge SJ.
Science
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Science
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Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p.
Authors: Authors: Gasch AP, Huang M, Metzner S, Botstein D, Elledge SJ, Brown PO.
Mol Biol Cell
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Mol Biol Cell
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Reduced expression and impaired kinase activity of a Chk2 mutant identified in human lung cancer.
Authors: Authors: Matsuoka S, Nakagawa T, Masuda A, Haruki N, Elledge SJ, Takahashi T.
Cancer Res
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Cancer Res
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Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function.
Direct DNA binding by Brca1.
Authors: Authors: Paull TT, Cortez D, Bowers B, Elledge SJ, Gellert M.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Asf1 links Rad53 to control of chromatin assembly.
The cellular chamber of doom.
Transcriptional regulation and function during the human cell cycle.
Authors: Authors: Cho RJ, Huang M, Campbell MJ, Dong H, Steinmetz L, Sapinoso L, Hampton G, Elledge SJ, Davis RW, Lockhart DJ.
Nat Genet
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Nat Genet
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Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.
Authors: Authors: Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, Abraham RT.
Genes Dev
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Genes Dev
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The DNA damage response: putting checkpoints in perspective.