Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination.
Authors: Authors: Gripp KW, Wotton D, Edwards MC, Roessler E, Ades L, Meinecke P, Richieri-Costa A, Zackai EH, Massagué J, Muenke M, Elledge SJ.
Nat Genet
View full abstract on Pubmed
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Authors: Authors: Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J.
Genes Dev
View full abstract on Pubmed
DNA damage-induced activation of p53 by the checkpoint kinase Chk2.
Authors: Authors: Hirao A, Kong YY, Matsuoka S, Wakeham A, Ruland J, Yoshida H, Liu D, Elledge SJ, Mak TW.
Science
View full abstract on Pubmed
The multifunctional character of a geminivirus replication protein is reflected by its complex oligomerization properties.
Authors: Authors: Orozco BM, Kong LJ, Batts LA, Elledge S, Hanley-Bowdoin L.
J Biol Chem
View full abstract on Pubmed
p53 sends nucleotides to repair DNA.
Authors: Authors: Lozano G, Elledge SJ.
Nature
View full abstract on Pubmed
The FHA domain, a phosphoamino acid binding domain involved in the DNA damage response pathway.
Authors: Authors: Huang M, Elledge SJ.
Cold Spring Harb Symp Quant Biol
View full abstract on Pubmed
Rapid construction of recombinant DNA by the univector plasmid-fusion system.
Authors: Authors: Liu Q, Li MZ, Liu D, Elledge SJ.
Methods Enzymol
View full abstract on Pubmed
Oppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome.
Authors: Authors: Caspary T, Cleary MA, Perlman EJ, Zhang P, Elledge SJ, Tilghman SM.
Genes Dev
View full abstract on Pubmed
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.
Authors: Authors: Cortez D, Wang Y, Qin J, Elledge SJ.
Science
View full abstract on Pubmed
Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.
Authors: Authors: Sanchez Y, Bachant J, Wang H, Hu F, Liu D, Tetzlaff M, Elledge SJ.
Science
View full abstract on Pubmed