Stephen J. Elledge, Ph.D.
Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway.
Authors: Authors: Desany BA, Alcasabas AA, Bachant JB, Elledge SJ.
Genes Dev
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Genes Dev
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The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor.
Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity.
The role of protein stability in the cell cycle and cancer.
Mitotic arrest: Mad2 prevents sleepy from waking up the APC.
The role of Cdk7 in CAK function, a retro-retrospective.
G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts.
Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells.
Authors: Authors: Edwards MC, Liegeois N, Horecka J, DePinho RA, Sprague GF, Tyers M, Elledge SJ.
Genetics
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Genetics
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F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.
Authors: Authors: Skowyra D, Craig KL, Tyers M, Elledge SJ, Harper JW.
Cell
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Cell
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Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae.