Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex.
Authors: Authors: Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P.
Mol Cell
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How the cyclin became a cyclin: regulated proteolysis in the cell cycle.
Authors: Authors: Koepp DM, Harper JW, Elledge SJ.
Cell
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Skipping into the E2F1-destruction pathway.
Authors: Authors: Harper JW, Elledge SJ.
Nat Cell Biol
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Mitotic treasures in the nucleolus.
Authors: Authors: Bachant JB, Elledge SJ.
Nature
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Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.
Authors: Authors: Skowyra D, Koepp DM, Kamura T, Conrad MN, Conaway RC, Conaway JW, Elledge SJ, Harper JW.
Science
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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.
Authors: Authors: Kamura T, Koepp DM, Conrad MN, Skowyra D, Moreland RJ, Iliopoulos O, Lane WS, Kaelin WG, Elledge SJ, Conaway RC, Harper JW, Conaway JW.
Science
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DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae.
Authors: Authors: Wang H, Elledge SJ.
Proc Natl Acad Sci U S A
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The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.
Authors: Authors: Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW.
Genes Dev
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p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step.
Authors: Authors: Zhang P, Wong C, Liu D, Finegold M, Harper JW, Elledge SJ.
Genes Dev
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Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo.
Authors: Authors: Gómez Lahoz E, Liegeois NJ, Zhang P, Engelman JA, Horner J, Silverman A, Burde R, Roussel MF, Sherr CJ, Elledge SJ, DePinho RA.
Mol Cell Biol
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