Stephen J. Elledge, Ph.D.
Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
PAT1, an evolutionarily conserved acetyltransferase homologue, is required for multiple steps in the cell cycle.
A question of balance: the role of cyclin-kinase inhibitors in development and tumorigenesis.
The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment.
Authors: Authors: Siede W, Allen JB, Elledge SJ, Friedberg EC.
J Bacteriol
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J Bacteriol
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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.
Authors: Authors: Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, Elledge SJ.
Cell
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Cell
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Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15.
Authors: Authors: Matsuoka S, Thompson JS, Edwards MC, Bartletta JM, Grundy P, Kalikin LM, Harper JW, Elledge SJ, Feinberg AP.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5.
Authors: Authors: Kondo M, Matsuoka S, Uchida K, Osada H, Nagatake M, Takagi K, Harper JW, Takahashi T, Elledge SJ, Takahashi T.
Oncogene
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Oncogene
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Cdk inhibitors in development and cancer.
Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways.
Authors: Authors: Sanchez Y, Desany BA, Jones WJ, Liu Q, Wang B, Elledge SJ.
Science
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Science
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Gene identification using the yeast two-hybrid system.
Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53.