Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.
Authors: Authors: Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, Elledge SJ.
Cell
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Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15.
Authors: Authors: Matsuoka S, Thompson JS, Edwards MC, Bartletta JM, Grundy P, Kalikin LM, Harper JW, Elledge SJ, Feinberg AP.
Proc Natl Acad Sci U S A
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Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5.
Authors: Authors: Kondo M, Matsuoka S, Uchida K, Osada H, Nagatake M, Takagi K, Harper JW, Takahashi T, Elledge SJ, Takahashi T.
Oncogene
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Cdk inhibitors in development and cancer.
Authors: Authors: Harper JW, Elledge SJ.
Curr Opin Genet Dev
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Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways.
Authors: Authors: Sanchez Y, Desany BA, Jones WJ, Liu Q, Wang B, Elledge SJ.
Science
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Gene identification using the yeast two-hybrid system.
Authors: Authors: Bai C, Elledge SJ.
Methods Enzymol
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Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53.
Authors: Authors: Helps NR, Barker HM, Elledge SJ, Cohen PT.
FEBS Lett
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Multiple genetic loci within 11p15 defined by Beckwith-Wiedemann syndrome rearrangement breakpoints and subchromosomal transferable fragments.
Authors: Authors: Hoovers JM, Kalikin LM, Johnson LA, Alders M, Redeker B, Law DJ, Bliek J, Steenman M, Benedict M, Wiegant J, Lengauer C, Taillon-Miller P, Schlessinger D, Edwards MC, Elledge SJ, Ivens A, Westerveld A, Little P, Mannens M, Feinberg AP.
Proc Natl Acad Sci U S A
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Finding prospective partners in the library: the two-hybrid system and phage display find a match.
Authors: Authors: Allen JB, Walberg MW, Edwards MC, Elledge SJ.
Trends Biochem Sci
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In vivo gene therapy with p53 or p21 adenovirus for prostate cancer.
Authors: Authors: Eastham JA, Hall SJ, Sehgal I, Wang J, Timme TL, Yang G, Connell-Crowley L, Elledge SJ, Zhang WW, Harper JW, et al.
Cancer Res
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