Stephen J. Elledge, Ph.D.
Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle.
Authors: Authors: Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM.
Science
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Science
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Isolation of crt mutants constitutive for transcription of the DNA damage inducible gene RNR3 in Saccharomyces cerevisiae.
CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle.
Authors: Authors: Elledge SJ, Richman R, Hall FL, Williams RT, Lodgson N, Harper JW.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Ribonucleotide reductase: regulation, regulation, regulation.
Isolation of temperature-sensitive diphtheria toxins in yeast and their effects on Drosophila cells.
Authors: Authors: Bellen HJ, D'Evelyn D, Harvey M, Elledge SJ.
Development
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Development
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A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.
Lambda YES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations.
Authors: Authors: Elledge SJ, Mulligan JT, Ramer SW, Spottswood M, Davis RW.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase.
Gene targeting at the human CD4 locus by epitope addition.
Identification of the DNA damage-responsive element of RNR2 and evidence that four distinct cellular factors bind it.