Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes.
Authors: Authors: Kula T, Dezfulian MH, Wang CI, Abdelfattah NS, Hartman ZC, Wucherpfennig KW, Lyerly HK, Elledge SJ.
Cell
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Natural selection contributed to immunological differences between hunter-gatherers and agriculturalists.
Authors: Authors: Harrison GF, Sanz J, Boulais J, Mina MJ, Grenier JC, Leng Y, Dumaine A, Yotova V, Bergey CM, Nsobya SL, Elledge SJ, Schurr E, Quintana-Murci L, Perry GH, Barreiro LB.
Nat Ecol Evol
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Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells.
Authors: Authors: Zirin J, Ni X, Sack LM, Yang-Zhou D, Hu Y, Brathwaite R, Bulyk ML, Elledge SJ, Perrimon N.
Proc Natl Acad Sci U S A
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A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation.
Authors: Authors: Timms RT, Zhang Z, Rhee DY, Harper JW, Koren I, Elledge SJ.
Science
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Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions.
Authors: Authors: Kong W, Hayashi T, Fiches G, Xu Q, Li MZ, Que J, Liu S, Zhang W, Qi J, Santoso N, Elledge SJ, Zhu J.
Genomics Proteomics Bioinformatics
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Temporal virus serological profiling of kidney graft recipients using VirScan.
Authors: Authors: Isnard P, Kula T, Avettand Fenoel V, Anglicheau D, Terzi F, Legendre C, Elledge SJ, Canaud G.
Proc Natl Acad Sci U S A
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Comprehensive Profiling of HIV Antibody Evolution.
Authors: Authors: Eshleman SH, Laeyendecker O, Kammers K, Chen A, Sivay MV, Kottapalli S, Sie BM, Yuan T, Monaco DR, Mohan D, Wansley D, Kula T, Morrison C, Elledge SJ, Brookmeyer R, Ruczinski I, Larman HB.
Cell Rep
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MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas.
Authors: Authors: Maertens O, Kuzmickas R, Manchester HE, Emerson CE, Gavin AG, Guild CJ, Wong TC, De Raedt T, Bowman-Colin C, Hatchi E, Garraway LA, Flaherty KT, Pathania S, Elledge SJ, Cichowski K.
Cancer Discov
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Tissue-specificity in cancer: The rule, not the exception.
Authors: Authors: Haigis KM, Cichowski K, Elledge SJ.
Science
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Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.
Authors: Authors: Mengwasser KE, Adeyemi RO, Leng Y, Choi MY, Clairmont C, D'Andrea AD, Elledge SJ.
Mol Cell
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