Gary B. Ruvkun, Ph.D.
Professor of Genetics, Harvard Medical School
Department of Molecular Biology, Massachusetts General Hospital
Computational and experimental identification of C. elegans microRNAs.
Authors: Authors: Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J.
Mol Cell
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Mol Cell
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DAF-16 target genes that control C. elegans life-span and metabolism.
daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway.
A uniform system for microRNA annotation.
Authors: Authors: Ambros V, Bartel B, Bartel DP, Burge CB, Carrington JC, Chen X, Dreyfuss G, Eddy SR, Griffiths-Jones S, Marshall M, Matzke M, Ruvkun G, Tuschl T.
RNA
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RNA
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Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes.
Authors: Authors: Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G.
Nature
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Nature
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Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution?
Authors: Authors: Pasquinelli AE, McCoy A, Jiménez E, Saló E, Ruvkun G, Martindale MQ, Baguñà J.
Evol Dev
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Evol Dev
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A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity.
Authors: Authors: Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G.
Nat Genet
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Nat Genet
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Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway.
Authors: Authors: Wolkow CA, Muñoz MJ, Riddle DL, Ruvkun G.
J Biol Chem
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J Biol Chem
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The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons.
Longevity: don't hold your breath.