
Gary B. Ruvkun, Ph.D.
Professor of Genetics, Harvard Medical School
Department of Molecular Biology, Massachusetts General Hospital
Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning.
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA.
Authors: Authors: Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun G.
Nature
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Nature
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Graded expression of ceh-14 reporters in the hypodermis is induced by a gonadal signal.
Authors: Authors: Kagoshima H, Sommer R, Reinhart BJ, Cassata G, Ruvkun G, Bürglin TR.
Dev Genes Evol
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Dev Genes Evol
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Regulation of C. elegans life-span by insulinlike signaling in the nervous system.
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells.
Authors: Authors: Nasrin N, Ogg S, Cahill CM, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges MC.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor.
Authors: Authors: Slack FJ, Basson M, Liu Z, Ambros V, Horvitz HR, Ruvkun G.
Mol Cell
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Mol Cell
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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans.
Authors: Authors: Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G.
Nature
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Nature
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Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant.
A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum.
Authors: Authors: Tissenbaum HA, Hawdon J, Perregaux M, Hotez P, Guarente L, Ruvkun G.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Themes from a NASA workshop on gene regulatory processes in development and evolution.