Richard Mulligan headshot

Richard Charles Mulligan, Ph.D

Mallinckrodt Professor of Genetics and Professor of Pediatrics, Emeritus

Richard C. Mulligan is the Mallinckrodt Professor of Genetics at Harvard Medical School, and Director of the Harvard Gene Therapy Initiative, an integrated effort amongst basic science and clinical investigators at Harvard University and its Affiliated Hospitals directed towards the pre-clinical and clinical evaluation of novel gene-based therapies for inherited and acquired diseases. Professor Mulligan received his B.S. degree from Massachusetts Institute of Technology, and his Ph.D. from the Department of Biochemistry at Stanford University School of Medicine, where he studied under Professor Paul Berg. After receiving postdoctoral training at the Center for Cancer Research at MIT with Professors David Baltimore and Phillip Sharp, Professor Mulligan joined the MIT faculty and subsequently was appointed Professor of Molecular Biology and Member of the Whitehead Institute for Biomedical Research before moving to Children's Hospital and Harvard in 1996. His honors include the MacArthur Foundation Prize, the Rhodes Memorial Award of the American Association for Cancer Research, the ASMB-Amgen Award, and the Nagai Foundation International Prize.

Professor Mulligan is an internationally recognized pioneer in the development of new technologies for transferring genes into mammalian cells. Scientists use the specialized tools created in his laboratory to unravel basic questions about human development and to devise new therapies for the treatment of both inherited diseases and acquired diseases.

Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges.
Authors: Authors: Danos O, Mulligan RC.
Proc Natl Acad Sci U S A
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Correction of the genetic defect in hepatocytes from the Watanabe heritable hyperlipidemic rabbit.
Authors: Authors: Wilson JM, Johnston DE, Jefferson DM, Mulligan RC.
Proc Natl Acad Sci U S A
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Retroviral-mediated transfer and expression of human beta-globin genes in cultured murine and human erythroid cells.
Authors: Authors: Weber-Benarous A, Cone RD, London IM, Mulligan RC.
J Biol Chem
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Retrovirus-mediated transduction of adult hepatocytes.
Authors: Authors: Wilson JM, Jefferson DM, Chowdhury JR, Novikoff PM, Johnston DE, Mulligan RC.
Proc Natl Acad Sci U S A
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Retroviral transfer of a murine cDNA for multidrug resistance confers pleiotropic drug resistance to cells without prior drug selection.
Authors: Authors: Guild BC, Mulligan RC, Gros P, Housman DE.
Proc Natl Acad Sci U S A
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Lineage-specific expression of a human beta-globin gene in murine bone marrow transplant recipients reconstituted with retrovirus-transduced stem cells.
Authors: Authors: Dzierzak EA, Papayannopoulou T, Mulligan RC.
Nature
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Lineage specific expression of a human beta-globin gene in murine bone marrow transplant recipients.
Authors: Authors: Dzierzak EA, Mulligan RC.
Adv Exp Med Biol
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Expression of HLA-DR antigen in human class II mutant B-cell lines by double infection with retrovirus vectors.
Authors: Authors: Yang Z, Korman AJ, Cooper J, Pious D, Accolla RS, Mulligan RC, Strominger JL.
Mol Cell Biol
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Expression of an exogenous growth hormone gene by transplantable human epidermal cells.
Authors: Authors: Morgan JR, Barrandon Y, Green H, Mulligan RC.
Science
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Retroviral expression of the human IL-2 gene in a murine T cell line results in cell growth autonomy and tumorigenicity.
Authors: Authors: Yamada G, Kitamura Y, Sonoda H, Harada H, Taki S, Mulligan RC, Osawa H, Diamantstein T, Yokoyama S, Taniguchi T.
EMBO J
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